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Buy Bulk GHRP-6 5mg

Unit Size 5 mg/vial
Unit Quantity 1 vial
Purity (HPLC) 99.03%
Sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Molecular Formula C46H56N12O6
Molecular Weight 873.01
Appearance lyophilized White Powder
Source Chemical Synthesis
Storage
Lyophilized GHRP-6 is Stable at room
Temperature for 90 days, however it is best to store in a freezer
below - 8c for any extended
period of time. After reconstitution GHRP-6 should be
refrigerated at temperatures not to exceed 35 F.
Terms The products we offer are intended for laboratory
research use only. Please familiarize yourself with
our terms of service prior to ordering.

GHRP-6 (growth hormone releasing peptide 6) is a synthetic compound made of six amino acids. It can elicit the release of growth hormone (GH)1. Early work on GHRP-6 and similar peptides indicated that they have no structural similarity to growth hormone releasing hormone, however2. There are two analogs of GHRP-6; GHRP-6 peptide and [D-Lys-3]-GHRP-6. [D-Lys-3]-GHRP-6 has an antagonist effect on the GH secretagogue receptor (GHS-R), or the receptor for ghrelin3. Therefore, such a peptide may be used in animal studies that assess the role of this important biomolecule in various processes related to hunger and metabolic regulation. For example, ghrelin may have a role in enhancing the release of insulin in response to food intake, through the release of GLP-1 from specialized cells in the intestine4. [D-Lys-3]-GHRP-6 has demonstrated the ability to counteract this effect4. It may also be used to determine the locations of the GHS-R, e.g. in the ventral tegmental area of the brain3. [D-Lys-3]-GHRP-6 has demonstrated the ability to reduce the extent of DNA synthesis in the gastric glands of infant rats, indicating a role for ghrelin in the development of the stomach after birth5.

The GHRP-6 peptide, on the other hand, has a dose-dependent agonist effect on the GHS receptor6. However, it appears not to match ghrelin in terms of specificity6. GHRP-6 has demonstrated positive effects on organ growth and regeneration in various studies. Its administration resulted in a threefold increase in the migration, but not proliferation, of rat-intestine epithelial cells, indicating a role for the peptide in restoring gut function7. Intraperitoneal GHRP-6 peptide (at a concentration of 120 μg/kg) also significantly inhibited the effects of an animal model of multiple organ damage (i.e. ischemia-reperfusion injury)7. A combination of GHRP-6 and recombinant human epidermal growth factor (administered at concentrations of either 100 or 600 μg per kg) had a significantly detrimental effects on the neurological damage expected as a result of experimentally-induced ischemic stroke in gerbils8.

References: 1. Pimentel-Filho FR, Ramos-Dias JC, Ninno FB, Facanha CF, Liberman B, Lengyel AM. Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism. Clinical endocrinology. 1997;46(3):295-300. 2. Ghigo E, Arvat E, Muccioli G, Camanni F. Growth hormone-releasing peptides. European journal of endocrinology / European Federation of Endocrine Societies. 1997;136(5):445-460. 3. St-Onge V, Watts A, Abizaid A. Ghrelin enhances cue-induced bar pressing for high fat food. Hormones and behavior. 2015;78:141-149. 4. Gagnon J, Baggio LL, Drucker DJ, Brubaker PL. Ghrelin Is a Novel Regulator of GLP-1 Secretion. Diabetes. 2015;64(5):1513-1521. 5. Bittar NM, Zulian JG, Ogias D, Gama P. Ghrelin and GHS-R in the rat gastric mucosa: Are they involved in regulation of growth during early weaning? Nutrition (Burbank, Los Angeles County, Calif.). 2016;32(1):101-107. 6. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-660. 7. Cibrian D, Ajamieh H, Berlanga J, et al. Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure. Clinical science (London, England : 1979). 2006;110(5):563-573. 8. Subiros N, Perez-Saad HM, Berlanga JA, et al. Assessment of dose-effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy. Neurological research. 2015:1743132815y0000000089.

View FileGHRP-6 CertifIcate of Analysis    Size: (636.12 KB)
View FileGHRP-6 HPLC Report    Size: (659.63 KB)
View FileGHRP-6 Mass Spectrum Report    Size: (524.44 KB)
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    (Posted on 7/11/2015)


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