GHRP-6 5mg

GHRP-6, or growth hormone-releasing peptide 6, is a synthetic mimetic of ghrelin. This peptide is classified as a growth hormone secretagogue, studied for its ability to bind to the growth hormone secretagogue receptor (GHS-R). Research has characterized the GHS-R receptor's natural binding to ghrelin, the endogenous ligand associated with regulating hunger, food intake, and growth hormone (GH) secretion.¹

Unlike growth hormone-releasing hormone (GHRH), GHRP-6 does not share any amino acid sequence and binds to different receptors. Research has examined co-administration of GHRP-6 with GHRH for its combined effects on GH-related signaling via the hypothalamus and pituitary gland in laboratory models.

GHRP-6 is composed of six amino acids, including two unnatural D-amino acids, and has a molecular weight of 872.45 g/mol. Its amino acid sequence is as follows:

• L-Histidine
• D-Tryptophan
• L-Alanine
• L-Tryptophan
• D-Phenylalanine
• L-Lysine

The incorporation of D-amino acids is associated with enhanced stability of GHRP-6, and laboratory research has examined its effects on GH secretion from the anterior pituitary and on somatostatin signaling in experimental models. Related research has examined downstream effects on insulin-like growth factor (IGF) signaling pathways involved in metabolism, protein synthesis, and cell proliferation.¹

Animal Model Research

In an aquaculture study, feed supplementation with GHRP-6 at doses of 100 µg/kg or 500 µg/kg was examined for its effects on growth performance markers in fish. The lower dose was associated with changes in aerobic metabolism markers, while the higher dose was associated with elevated GH levels comparable to those induced by ghrelin.¹ Separately, GHRP-6 has been studied in a gerbil model of induced cerebral ischemia, where co-administration of GHRP-6 with recombinant epidermal growth factor (rhEGF) was examined for its effects on survival and neurological function markers in the model.²

Important Notice

GHRP-6 is intended exclusively for in vitro and in vivo (animal) laboratory research purposes and is not approved for human or veterinary use. It must be handled according to all applicable safety and research protocols, and has not been evaluated for safety or efficacy in humans or animals outside of controlled research.

References

1. Rodriguez-Viera L, Marti I, Martinez R, et al. Feed supplementation with the GHRP-6 peptide, a ghrelin analog, improves feed intake, growth performance, and aerobic metabolism in the gilthead sea bream Sparus aurata. Fishes. 2022;7:31.
2. Subiros N, Perez-Saad HM, Berlanga JA, et al. Assessment of dose-effect and therapeutic time window in rhEGF and GHRP-6 co-administration for stroke therapy. Neurol Res. 2016;28(3):187-195.