FRAGMENT 176-191 2mg

Fragment 176-191 is a synthetic 16-amino-acid peptide corresponding to residues 176 through 191 at the C-terminus of human growth hormone (hGH), with a molecular weight of approximately 1799 g/mol.¹

Sequence Relative to Related Analogs

Fragment 176-191 begins with phenylalanine at its N-terminus, matching the native hGH sequence. It is distinct from AOD-9604, a related analog that carries tyrosine in that position, and the two compounds differ in molecular formula and mass.

Separation from the IGF-1-Associated Domain

A recurring theme in laboratory research on Fragment 176-191 is its structural separation from the region of hGH responsible for stimulating insulin-like growth factor-1 (IGF-1) release, which resides in a different domain of the full-length hormone.

Because this fragment excludes that domain, researchers have used it in cell-based systems to study the C-terminal region separately, without the confounding variable of concurrent IGF-1 elevation seen with full-length hGH.

Vial Sizing Across the Product Line

A 2 mg vial provides a smaller total peptide mass than the 5 mg unit size, making it a practical choice for laboratories running lower-volume or single-assay experimental designs rather than larger comparative studies spanning multiple conditions.

Researchers comparing purity data across unit sizes are encouraged to confirm they are referencing the correct lot-specific certificate of analysis.

Analytical Documentation Across Production Batches

As with other synthetic research peptides, batch-to-batch analytical documentation is a relevant consideration for Fragment 176-191, since variation in counterion content (commonly acetate, from the HPLC purification process) can affect net peptide content per milligram of lyophilized powder even at a constant purity percentage.

Researchers designing experiments that depend on precise molar concentration are encouraged to consult lot-specific certificates of analysis, which typically report peptide content alongside purity, to account for this variability.

Product Information

Fragment 176-191 is supplied as a lyophilized white powder at 2 mg per vial.

Important Notice

This product is intended for laboratory research use (in vitro) only. It is not approved for human use under any circumstances, and has not been evaluated for safety or efficacy in humans.

References

1. Harvey S, Martinez-Moreno CG. Growth Hormone: Therapeutic Possibilities—An Overview. Int J Mol Sci. 2018;19(7):2015.