Buy Bulk CJC-1295 W-DAC 2mg (No Promo Codes)

CJC-1295 W-DAC 2mg is a synthetic analog of human growth hormone-releasing hormone (GHRH) containing a drug affinity complex (DAC). This complex enables the covalent binding (conjugation) of CJC-1295 to endogenous albumin. As a result, the half-life of CJC-1295 is extended to a duration similar to that of albumin. This specific characteristic allows CJC-1295 to have an extended half-life and prolonged effects within the body¹. Animal studies have shown that a single administration of CJC-1295 can lead to sustained elevation of insulin-like growth factor-I (IGF-I) levels in the bloodstream, even several days after the initial dose.²

CJC-1295 has been extensively studied in animal models to evaluate its impact on growth hormone secretion, body composition, and metabolism. It is primarily used to enhance levels of endogenous growth hormone by increasing the pulsatile release of growth hormone from the pituitary gland.¹ Alba et al. conducted a research study to explore the impact of extended treatment with CJC-1295 on somatotroph cell proliferation, growth hormone production, and IGF-I secretion, as well as growth and body composition in GHRH knockout mice.³ In this study, three groups of one-week-old GHRH knockout mice were subjected to a five-week treatment regimen with 2 μg of CJC-1295 administered at intervals of 24, 48, and 72 hours. GHRH knockout animals that received daily doses of CJC-1295 showed normal body weight and length. However, mice treated every 48 and 72 hours exhibited higher body weight and length compared to the placebo-treated animals. These results show the potential of

CJC-1295 peptide for use in body composition and growth studies in labs.

Further, studies indicate that exogenous administration of growth hormone secretagogues or growth hormone analogs is enough to cause appropriate ovulation. In one such study, to investigate growth hormone’s direct effects on ovarian cells, granulosa cells from rats were cultured with follicle-stimulating hormone (FSH) in the presence or absence of growth hormone. Growth hormone enhanced FSH-induced LH receptor formation, steroid production, and cAMP production in granulosa cells. It increased luteinizing hormone (LH) receptor content by elevating receptor numbers, not affinity. Growth hormone also enhanced FSH-stimulated progesterone production but not estrogen production.⁵These findings suggest that growth hormone plays a regulatory role in ovarian follicular growth and pubertal development by augmenting gonadotropin-stimulated differentiation of granulosa cells.

References: 1. Jetté L et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005 Jul;146(7):3052-8. 2. Benquet C, Castaigne JP, Pham K, Robitaille M, and Frohman LA. CJC-1295 (DAC-GRF), a long-acting GRF analog, enhances pulsatile GH secretion, increases IGF-1 levels, and restores linear growth (Abstract). 86th Annual Meeting of The Endocrine Society, 2004, p. P3-109. 3. Alba M et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. 4. Jia XC, Kalmijn J, Hsueh AJ. Growth hormone enhances follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells. Endocrinology. 1986 Apr;118(4):1401-9.