Buy Bulk MELANOTAN II 10mg

Melanotan II is a synthetic, cyclic analog of alpha-melanocyte-stimulating hormone (α-MSH), studied in vitro as a non-selective agonist across multiple melanocortin receptor subtypes.

Lactam Cyclization and Conformational Constraint

Unlike native α-MSH, Melanotan II is cyclized through a lactam bridge linking its Asp and Lys side chains, a modification studied for constraining the peptide's conformation and increasing resistance to enzymatic breakdown relative to linear melanocortin fragments.

This cyclization is combined with two additional stabilizing changes: a norleucine substitution at the position corresponding to methionine in native α-MSH, removing a residue prone to oxidative degradation, and a D-phenylalanine substitution studied for its effect on metabolic stability in laboratory assay systems.

Melanogenesis Pathway Research

In vitro studies using B16F10 mouse melanoma cells, an established melanocyte-lineage cell line, found that α-MSH stimulation increased melanin content and tyrosinase enzyme activity within this cell-based system, alongside elevated expression of AhR, CTNNB1, and MITF, genes involved in the melanogenesis pathway.¹

Analytical Verification of Ring Closure

Because Melanotan II's biological activity depends on its cyclized structure, purity testing combines HPLC with mass spectrometry to confirm both correct ring closure and the absence of linear, non-cyclized synthesis byproducts that can co-occur during lactam bridge formation.

For bulk orders, researchers are encouraged to confirm that analytical data specifically addresses cyclization status for the batch supplied, rather than relying on HPLC retention time alone.

Storage and Handling in the Laboratory Setting

The lactam-cyclized structure, while more stable than a linear analog, remains susceptible to degradation once exposed to moisture or ambient conditions, making sub-zero freezer storage of the lyophilized powder standard practice.

Researchers working with a bulk order typically portion the lyophilized powder into several smaller vials under controlled laboratory conditions shortly after arrival, so that only a fraction of the total supply is exposed to light and temperature fluctuations each time material is withdrawn.

Important Notice

Melanotan II is intended exclusively for laboratory research use (in vitro) and is not approved for human use. Any application outside of controlled research settings is prohibited, and these findings do not establish safety, efficacy, or suitability for any human application.

Product Information

Melanotan II is supplied as a research reagent for laboratory use only, available in bulk quantity.

References

1. Ghaffarian-Bahraman A, Jamshidzadeh A, Keshavarzi M, Arabnezhad MR, Mohammadi H, Mohammadi-Bardbori A. α-Melanocyte-Stimulating Hormone Triggers Melanogenesis Via Activation of the Aryl Hydrocarbon Receptor Pathway in B16F10 Mouse Melanoma Cells. Int J Toxicol. 2021;40(2):153-160.