PT-141 (Bremelanotide) 10mg

PT-141 is a synthetically produced peptide commonly utilized in in vitro laboratory research to examine melanocortin receptor interactions and intracellular signaling mechanisms. Structurally, PT-141 is a short-chain peptide composed of a defined amino acid sequence that enables selective interaction with melanocortin receptor subtypes, particularly MC1R and MC4R, making it a valuable reagent for receptor-based studies.

In controlled laboratory environments, PT-141 is frequently employed in receptor binding assays, signal transduction experiments, and pathway-mapping studies. Its stability in lyophilized form allows for accurate reconstitution and reproducible experimental conditions, which are essential for high-precision biochemical research. Researchers utilize PT-141 to explore receptor activation dynamics, second messenger cascades, and downstream transcriptional responses associated with melanocortin signaling.

One area of investigation involves the use of PT-141 in cellular models engineered to express specific melanocortin receptor isoforms. In these systems, PT-141 functions as a reference agonist, enabling comparative analysis of receptor affinity, potency, and signaling bias. Such studies contribute to a broader understanding of G-protein–coupled receptor (GPCR) behavior and ligand-receptor specificity under controlled experimental conditions.

PT-141 is also utilized in studies examining intracellular calcium flux, cyclic AMP modulation, and kinase activation pathways. These experiments help clarify how melanocortin receptor engagement influences cellular communication networks. Data generated from these investigations are useful for refining assay design, validating analytical methods, and supporting computational modeling of receptor-ligand interactions.

From an analytical perspective, PT-141 serves as a benchmark compound in method development for peptide characterization. Techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and ultraviolet spectroscopy are commonly applied to confirm peptide integrity, purity, and stability. These analytical approaches ensure consistency across experimental batches and support reliable interpretation of research outcomes.

Handling and Compliance
PT-141 should be handled exclusively by qualified personnel in appropriate laboratory settings. Standard laboratory safety procedures, including the use of protective equipment and controlled storage conditions, are recommended. This compound is intended solely for experimental research and must be used in accordance with institutional guidelines and applicable regulations.

References

• Molinoff PB, et al. Melanocortin receptor ligands and signaling pathways in experimental systems.
• Hedlund P. Structure–activity relationships of melanocortin agonists in receptor-based assays.
• Pfaus J, et al. Characterization of peptide ligands interacting with melanocortin receptors in vitro.
• Mountjoy KG. Distribution and functional roles of melanocortin receptors in cellular research models.