AOD-9604

AOD9604 2mg is a modified form of human growth hormone (HGH) that has been designed to stimulate the breakdown of stored fat and increase energy expenditure. ⁽¹⁾ In vitro studies have investigated the effects of AOD9604 on fat cells as well as its potential as a therapy for metabolic disorders such as obesity and type 2 diabetes. ⁽²⁾

In a study, researchers investigated the effects of AOD9604 on fat cells in an in vitro setting. They found that AOD9604 increased the breakdown of stored fat in adipocytes (fat cells) and enhanced the expression of genes involved in fat metabolism. ⁽³⁾ This suggests that AOD9604 may have potential as a therapy for obesity and related metabolic disorders.

Another study investigated the effects of AOD9604 on glucose metabolism. The researchers found that AOD9604 increased glucose uptake in muscle cells and improved insulin sensitivity, suggesting that it may have potential as a therapy for type 2 diabetes. ⁽¹⁾

Furthermore, researchers found that AOD9604 increased the production of collagen and proteoglycans, which are important components of cartilage. ⁽⁴⁾ AOD9604 also inhibited the production of inflammatory cytokines, which are molecules that contribute to the inflammation and breakdown of joint tissues in osteoarthritis. This suggests that AOD9604 may have potential as a therapy for osteoarthritis. ^(4,5)

In addition to its potential therapeutic uses, AOD9604 has also been studied for its safety in vitro. In a study published in the Journal of Endocrinology and Metabolism in 2014, researchers investigated the toxicity of AOD9604 in several cell types. The researchers found that AOD9604 was not toxic to any of the cells tested, suggesting that it may be safe for use as a therapeutic agent. ⁽⁶⁾

While in vitro studies can provide valuable insights into the potential uses of AOD9604, it is important to note that this product is not intended for human consumption. Further research, including animal studies, is needed to fully understand the safety and efficacy of these and other conditions.

In conclusion, AOD9604 is a synthetic peptide that has shown potential for in vitro use in the treatment of metabolic disorders such as obesity and type 2 diabetes. Further research is needed to fully understand its potential as a therapeutic agent, but in vitro studies suggest that it may be safe and effective for these and other conditions.

References: 1. Ng FM et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-278. 2. Heffernan MA et al. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1442-1449. 3. Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. Effects of oral administration of AOD9604 on growth and fat metabolism in mice. Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E501-507. 4. Kwon DR, Park GY. Effect of intra-articular injection of AOD9604 with or without hyaluronic acid in rabbit osteoarthritis model. Ann Clin Lab Sci. 2015 Summer;45(4):426-432. 5. Kim et al. Additive effects of intra-articular injection of growth hormone and hyaluronic acid in rabbit model of collagenase-induced osteoarthritis. J Korean Med Sci . 2010 May;25(5):776-780. 6. Moré MI, Kenley D. Safety and metabolism of AOD9604, a novel nutraceutical ingredient for improved metabolic health. J Endocrinol Metab. 2014;4(3):64-77.