HEXARELIN 2mg

Hexarelin is a synthetic analog of the gastrointestinal peptide ghrelin, studied in laboratory research for its interaction with the growth hormone secretagogue receptor (GHS-R), found in the brain and cardiovascular system.¹ Hexarelin primarily targets GHS-R 1a, located in various tissues, including the pituitary gland and heart. Unlike ghrelin, hexarelin also binds to the CD36 receptor, imparting additional receptor-binding properties of research interest.¹ Hexarelin consists of 6 amino acids with a molecular weight of approximately 886 g/mol, making it significantly smaller than ghrelin, which has 28 amino acids.¹

Research comparing hexarelin to ghrelin in animal models has examined receptor binding characteristics and chemical stability. This peptide has been studied in laboratory research to explore ghrelin-related receptor pathways and their downstream biological signaling in animal models.

Cardiovascular and Pulmonary Research Models

In animal model studies, hexarelin administration was associated with reduced markers of cardiac fibrosis following induced myocardial injury, with researchers noting an interaction with the angiotensin-converting enzyme (ACE) system as a possible mechanism.² Separate animal studies observed changes in inflammatory signaling markers in models of acute lung injury and myocardial ischemia-reperfusion, along with reduced collagen deposition markers in lung fibrosis models.^2,3 These are laboratory observations in animal models and do not establish safety or efficacy for any application in humans or animals outside of controlled research.

Cellular Research Findings

At the cellular level, laboratory studies have examined hexarelin's effects on mitochondrial markers in cardiac and skeletal muscle cell models, and its effect on hydrogen peroxide-induced cell stress responses in Neuro-2A cells (a murine neuroblastoma cell line), noting effects on MAP kinase signaling pathways.³

Important Notice

Hexarelin is intended exclusively for in vitro and in vivo (animal) laboratory research purposes and is not approved for human or veterinary use. This product has not been evaluated for safety or efficacy in humans or animals outside of controlled research settings. Proper handling according to safety protocols and research guidelines is essential. Any use for diagnostic or therapeutic applications is strictly prohibited.

References

1. Mao Y, Tokudome T, Kishimoto I. The cardiovascular action of hexarelin. J Geriatr Cardiol. 2014 Sep;11(3):253-258.
2. Zambelli V, Rizzi L, Delvecchio P, Bresciani E, et al. Hexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injury. Drug Target Insights. 2021;15:26-33.
3. McDonald H, Peart J, Kurniawan ND, Galloway G, et al. Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in myocardial ischemia-reperfusion models. Biomed Pharmacother. 2020 Jul;127:110165.