Thymosin Beta 4 (TB500) 5mg

Thymosin Beta-4 (TB-4) Peptide for In Vitro Research – Thymosin beta-4, also known as TB-4, is a naturally occurring peptide found in all body cells except red blood cells (erythrocytes). Comprising 43 amino acids and with a molecular weight of 4.9 kDa, TB-4 binds to the G-actin cytoskeleton, promoting cell migration, proliferation, and differentiation, which are essential in wound healing and tissue regeneration research.¹ This peptide is highly concentrated at injury sites, released by platelets and macrophages to support the body’s first response to injury.²

Due to its mobilizing and angiogenic properties, thymosin beta-4 is a popular peptide in controlled in vitro and in vivo models for cardiac injury, ischemia, stroke, liver fibrosis, and corneal healing research.² Both chemically synthesized and recombinant forms of thymosin beta-4 are utilized strictly in laboratory environments. For example, in coronary ligation studies using mice, TB-4 has been observed to interact with Akt and integrin-linked kinase (ILK), supporting cardiomyocyte mobility and survival, which may enhance heart function.¹

In liver fibrosis research, an in vitro study using hematopoietic stem cells (HSCs) demonstrated that exogenous thymosin beta-4 could inhibit HSC proliferation, potentially mitigating fibrosis progression. The findings underscore the peptide's research relevance, though further studies are required to understand its full effects.³ Additionally, in corneal injury models, TB-4 has been shown to aid cell migration and differentiation in avascular tissues, supporting wound healing without fibrosis.⁴

Product Information: Thymosin beta-4 (TB-4) is provided as a lyophilized white powder in 5 mg vials and is intended exclusively for in vitro laboratory research. It is not suitable for human or animal use outside controlled research settings.

References:
1. Aronson JK. (2016). Thymic hormones. In Aronson’s Meyler’s Side Effects of Drugs. doi: 10.1016/B978-0-444-53717-1.00190-6.
2. Kleinman HK, Sosne G. (2016). Thymosins. In Litwack G (Ed.) Vitamins and Hormones (pp. 251-275). Elsevier. doi: 10.1016/bs.vh.2016.04.005.
3. Kim J, Jung Y. (2016). Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells. In Litwack G (Ed). Vitamins and Hormones (pp 121-149). Elsevier. doi: 10.1016/bs.vh.2016.04.011.
4. Sosne G, Qiu P, Kurpakus-Wheater M. Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent. Clin Ophthalmol. 2007 Sep;1(3):201-207.