Epithalon Peptide 10mg

Epithalon peptide is a synthetic peptide that mimics the naturally occurring protein epithalamin. Comprising just four amino acids—alanine, glutamic acid, asparagine, and glycine—Epithalon (also known as epitalon) has a molecular mass of 390 g/mol. This peptide is produced by the pineal gland in the brain and plays a vital role in regulating circadian rhythms and melatonin secretion.¹

Biological Functions

Research on Epithalon has shown its various functions in animal models, including:

• Increasing melatonin production in response to light-dark signals.
• Exhibiting anti-inflammatory and antioxidant effects.
• Improving immune parameters.
• Demonstrating anticarcinogenic potential.

Known as the AEDG peptide (named after its constituent amino acids), Epithalon has been investigated for its ability to upregulate telomerase, which contributes to anti-aging and anti-tumorigenic effects.²

Cellular Aging and Longevity

In vitro studies have indicated that Epithalon can extend the lifespan of human fibroblast cell lines by allowing them to surpass the Hayflick limit, the point at which cells enter senescence. One study reported that Epithalon-treated cells could undergo over 44 passages, compared to just 34 passages for control cells.³ Additionally, in vivo studies on mouse models of aging have shown that Epithalon treatment reduces chromosomal abnormalities in both wild-type and accelerated-aging mice.⁴

Moreover, Epithalon combats free radicals associated with aging. In aging rat models, treatment with Epithalon enhanced the activity of antioxidant enzymes, including glutathione-S-transferase, superoxide dismutase, and glutathione peroxidase.⁵

Product Information

Epithalon is supplied as a lyophilized white powder in 10 mg vials.

Important Notice

This peptide is intended for in vitro laboratory research only. It is not approved for human or veterinary use.

References

1. Khavinson V, Diomede F, Mironova E, Linkova N, et al. AEGD Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020 Feb;25(3):609.
2. Khavinson V. Peptides and Ageing. Neuro Endocrinol Lett. 2022;23 Suppl 3:11-144.
3. Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2.
4. Khavinson VK, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cells. Bull Exp Biol Med. 2004 May;137(5):503-6.
5. Rosenfeld SV, Togo EF, Mikheev VS, Popovich IG, et al. Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice. Bull Exp Biol Med. 2002 Mar;133(3):274-6.
6. Kozina LS, Arutjunyan AV, Khavinson VK. Antioxidant properties of geroprotective peptides of the pineal gland. Arch Gerontol Geriatr. 2007;44 Suppl 1:213-6.