KLOW Blend (GHK-Cu, BPC-157, TB-500, KPV) 80mg

The KLOW Blend combines four synthetic peptides — GHK-Cu, BPC-157, Thymosin Beta 4 (TB-500), and KPV — into a single lyophilized formulation supplied for in vitro and in vivo (animal) laboratory research. Each component is studied for a distinct signaling mechanism, allowing researchers to examine multiple cellular pathways within a single reagent batch.

GHK-Cu Cell Signaling Research

GHK-Cu, or Glycyl-L-Histidyl-L-Lysine Copper(II), is a copper-binding tripeptide studied for its effects on cultured cell attachment and migration, collagen and glycosaminoglycan production, and gene expression related to oxidative stress, matrix remodeling, and cytokine signaling.^1,2

BPC-157 Cell Signaling Research

BPC-157 is a synthetic pentadecapeptide originally derived from a protein found in human gastric juice. It is studied in laboratory research for its interaction with cell signaling pathways related to tissue-level cell behavior, including nitric oxide signaling and endothelial cell function.^3,4

Thymosin Beta 4 (TB-500) Cytoskeletal Research

Thymosin Beta 4 is a protein isolate from the mammalian thymus gland, part of the thymosin family of low molecular weight acidic compounds. It is studied for its role in cell motility and differentiation, forming a 1:1 complex with monomeric actin (G-actin) to act as an actin buffer, relevant to laboratory research on cell migration and cell differentiation pathways.^5,6

KPV Inflammatory Signaling Research

KPV is a tripeptide composed of lysine, proline, and valine, derived from the C-terminal region of α-melanocyte-stimulating hormone (α-MSH). It is studied for its interaction with inflammatory signaling pathways, including effects on nuclear factor kappa B (NF-κB) activation and cytokine signaling in cultured immune and epithelial cell models.^7,8

Combined Research Applications

This four-peptide formulation is studied for research into matrix-related signaling, inflammatory signal pathways, and cell-level tissue models across multiple mechanisms within a single controlled research platform. Combined use of these peptides remains an area of exploratory laboratory research, and available data on multi-peptide interaction effects is preliminary and not considered conclusive.

Important Notice

The KLOW Blend is intended exclusively for in vitro and in vivo (animal) laboratory research and is not intended for human or animal consumption, diagnostic use, or therapeutic use. Any application outside of controlled laboratory research is strictly prohibited. These findings do not establish safety, efficacy, or suitability for any human or animal application, and this product has not been evaluated by the FDA or any regulatory agency.

Product Information

The KLOW Blend is supplied as an 80mg lyophilized white powder per vial, consisting of 50mg GHK-Cu, 10mg BPC-157, 10mg Thymosin Beta 4 (TB-500), and 10mg KPV, prepared exclusively for laboratory reconstitution and controlled experimental evaluation.

References

1. Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. Int J Mol Sci. 2012;13(7):8898-8917.
2. Maquart FX, Pickart L, Laurent M, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex GHK-Cu. FEBS Lett. 1988;238(2):343-346.
3. Hsieh MJ, Lee CH, Chueh HY, et al. Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway. Sci Rep. 2020;10:17078.
4. Seiwerth S, Milavic M, Vukojevic J, et al. Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Front Pharmacol. 2021;12:627533.
5. Goldstein AL, Slater FD, White A. Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin). Proc Natl Acad Sci U S A. 1966;56(3):1010-7.
6. Huff T, Müller CS, Otto AM, Netzker R, Hannappel E. Beta-Thymosins, small acidic peptides with multiple functions. Int J Biochem Cell Biol. 2001 Mar;33(3):205-20.
7. Catania A, Gatti S, Colombo G, Lipton JM. Targeting melanocortin receptors as a strategy to control inflammation. Pharmacol Rev. 2004;56(1):1–29.
8. Luger TA, Scholzen TE, Brzoska T, Böhm M. New insights into the functions of α-MSH and related peptides in immune regulation. Ann N Y Acad Sci. 2003;994:133–140.