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GHRP-6 (growth hormone-releasing peptide 6) is a synthetic compound composed of six amino acids studied strictly for in vitro laboratory research. It has demonstrated the ability to elicit the release of growth hormone (GH), though it has no structural similarity to endogenous growth hormone-releasing hormone (GHRH).^1,2 GHRP-6 is used only in controlled laboratory settings, not approved for human or veterinary applications.

There are two primary analogs of GHRP-6: GHRP-6 peptide and [D-Lys-3]-GHRP-6. [D-Lys-3]-GHRP-6 functions as an antagonist of the growth hormone secretagogue receptor (GHS-R), or ghrelin receptor.³ This peptide has shown potential in laboratory studies for assessing the role of ghrelin in metabolic processes, such as insulin release and GLP-1 regulation from intestinal cells in response to food intake.⁴ [D-Lys-3]-GHRP-6 may also help identify GHS-R locations, such as in the brain’s ventral tegmental area, and has shown effects on DNA synthesis in gastric cells, suggesting a role for ghrelin in postnatal stomach development.^3,5

GHRP-6 peptide acts as an agonist of the GHS-R in a dose-dependent manner.⁶ Although not as specific as ghrelin, GHRP-6 peptide has been used in lab studies exploring its impact on tissue growth and regeneration. Laboratory models demonstrated a threefold increase in cell migration, but not proliferation, in rat intestine cells treated with GHRP-6, indicating a role in gut function recovery.⁷ In animal models of ischemia-reperfusion injury, GHRP-6 was found to protect against organ damage, and in combination with recombinant human epidermal growth factor (rhEGF), GHRP-6 has been studied for its effects on neural damage from ischemic stroke.^7,8

Important Notice: GHRP-6 and [D-Lys-3]-GHRP-6 peptides are intended strictly for in vitro research. These compounds are not approved for human or veterinary use. All research must adhere to controlled laboratory protocols, as these peptides are solely for experimental use to study growth hormone release and ghrelin receptor interactions.

References:
1. Pimentel-Filho FR, Ramos-Dias JC, Ninno FB, Facanha CF, Liberman B, Lengyel AM. Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism. Clinical Endocrinology. 1997;46(3):295-300.
2. Ghigo E, Arvat E, Muccioli G, Camanni F. Growth hormone-releasing peptides. European Journal of Endocrinology. 1997;136(5):445-460.
3. St-Onge V, Watts A, Abizaid A. Ghrelin enhances cue-induced bar pressing for high-fat food. Hormones and Behavior. 2015;78:141-149.
4. Gagnon J, Baggio LL, Drucker DJ, Brubaker PL. Ghrelin is a novel regulator of GLP-1 secretion. Diabetes. 2015;64(5):1513-1521.
5. Bittar NM, Zulian JG, Ogias D, Gama P. Ghrelin and GHS-R in rat gastric mucosa: Are they involved in growth regulation during early weaning? Nutrition. 2016;32(1):101-107.
6. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from the stomach. Nature. 1999;402(6762):656-660.
7. Cibrian D, Ajamieh H, Berlanga J, et al. Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure. Clinical Science. 2006;110(5):563-573.
8. Subiros N, Perez-Saad HM, Berlanga JA, et al. Assessment of dose-effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy. Neurological Research. 2015:1743132815y0000000089.