Buy Bulk HEXARELIN 2mg

Hexarelin is a synthetic hexapeptide within the growth hormone-releasing peptide (GHRP) class, studied in vitro for receptor interactions extending beyond the growth hormone secretagogue receptor (GHS-R1a) that defines this peptide family.

CD36 as a Secondary Receptor Target

Unlike ghrelin, which activates GHS-R1a exclusively, hexarelin is also studied for its interaction with the CD36 scavenger receptor, a binding property not shared by other GHRP-class secretagogues built on the classical scaffold.

This dual-receptor profile makes hexarelin a distinct tool compound in receptor-binding assay design when researchers want to probe CD36-mediated signaling separately from classical GHS-R1a activity.

Oxidative Stress Signaling Research

Hydrogen peroxide exposure is a standard method for inducing oxidative stress in cultured neuronal cell models, allowing researchers to study protective signaling pathways activated in response.

In vitro studies using Neuro-2A cells, an established murine neuroblastoma cell line, found that hexarelin modulated MAP kinase and PI3K/Akt signaling pathways in this hydrogen-peroxide-challenge model, reducing apoptotic toxicity within the cell-based system.¹

Structural Basis for Elevated Receptor Affinity

Hexarelin builds on the earlier GHRP-6 scaffold with one key modification: a methyl group added to the D-tryptophan residue, distinguishing it from GHRP-6's unmethylated D-tryptophan at the same position.

Researchers studying structure-activity relationships among GHRP-class secretagogues have linked this 2-methyl substitution to hexarelin's comparatively higher binding affinity at GHS-R1a.

Analytical Purity Verification for Bulk Quantities

Hexarelin's two indole-containing tryptophan-derived residues, one bearing the 2-methyl substitution, are prone to side reactions during solid-phase synthesis.

For bulk orders, researchers are encouraged to confirm that HPLC and mass spectrometry data corresponds to the specific production batch supplied, given the synthesis complexity these residues introduce.

Storage and Handling in the Laboratory Setting

Lyophilized hexarelin is stored under sub-zero freezer conditions, with the powder kept away from light given the photosensitivity associated with its indole-containing residues.

Bulk shipments are typically divided into several smaller, light-shielded containers immediately upon receipt, an approach that limits how much of the total supply is exposed to ambient light and temperature during any single access.

Important Notice

Hexarelin is intended exclusively for laboratory research use (in vitro) and is not approved for human use. This product has not been evaluated for safety or efficacy in humans. Any use for diagnostic or therapeutic applications is strictly prohibited.

Product Information

Hexarelin is provided as a lyophilized powder at research-grade purity, available in bulk quantity for in vitro laboratory research.

References

1. Meanti R, Rizzi L, Bresciani E, Molteni L, Locatelli V, Coco S, Omeljaniuk RJ, Torsello A. Hexarelin modulation of MAPK and PI3K/Akt pathways in Neuro-2A cells inhibits hydrogen peroxide-induced apoptotic toxicity. Pharmaceuticals (Basel). 2021 May 8;14(5):444.