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Availability: In stock
Unit Size | 10 mg/ vial |
Unit Quantity | 1 vial |
Purity (Mass Spectrometry and UV) | 94.06% |
Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
Molecular Formula | C41H70N16O16S |
Molecular Mass | 1074.48 |
Synonyms | Acetyl Glutamyl Heptapeptide-3 |
Appearance | Lyophilized White Powder |
Source | Chemical Synthesis |
Storage |
Lyophilized SNAP-8 is Stable at room Temperature for 90 days, however it is best to store in a freezer below - 8c for any extended period of time. After reconstitution SNAP-8 should be refrigerated at temperatures not to exceed 35 F. |
Terms | The products we offer are intended for laboratory research use only. Please familiarize yourself with our terms of service prior to ordering. |
SNAP-8 is a synthetic neuropeptide composed of the N-terminal end of the SNAP-25 peptide. Also known as acetyl glutamyl heptapeptide-1, SNAP-8 has been used as a cosmetic peptide known for its anti-wrinkle and fine-line properties. It consists of 8 amino acids and has a molecular weight of 1074.5 g/mol. SNAP-25 interacts with the SNARE complex (specifically, syntaxin and synaptobrevin) to cellular transport and fusion of vesicles carrying neurotransmitters.1 SNAP-8 functions similarly to SNAP-25, but it does not bind exactly the same, destabilizing the complex slightly. As a result, the SNARE complex cannot facilitate the release of neurotransmitters such as catecholamine, subsequently reducing muscle contractions.2 In animal studies, the effects of SNAP-8 have shown to help the skin relax, preventing fine lines and wrinkles. SNAP-8 studies have also shown it can be used as an alternative to botulinum toxin injections for treating lines and wrinkles.3 Studies performed with SNAP-8, show that it is an effective treatment. One report with 17 subjects used silicon imprints to measure improvement of eye wrinkles after 28 days of treatment using a 10% formulation of SNAP-8. The results showed that there was a maximum wrinkle reduction of 62%, with a mean of 35%.4
Blue Sky Peptide’s SNAP-8 is available as a white lyophilized powder at a concentration of 10 mg/vial. SNAP-8 is intended for vitro scientific research.
References: 1. Han J, Pluhackova K, Bockmann RA. The Multifaceted Role of SNARE Proteins in Membrane Fusion. Front Physiol. 2017;8:5. 2. Gutierrez LM, Viniegra S, Rueda J, et al. A Peptide That Mimics the C-terminal Sequence of SNAP-25 Inhibits Secretory Vesicle Docking in Chromaffin Cells. J Biol Chem. 1997;272(5):2634-9. 3. Wongrattanakamon P, Nimmanpipug P, Sirithunyalug B, Jiranusornkul S. Molecular modeling elucidates the cellular mechanism of synaptotagmin-SNARE inhibition: a novel plausible route to anti-wrinkle activity of botox-like cosmetic active molecules. Mol Cell Biochem. 2018;42:97-109. 4. Errante F, Ledwon P, Latajka R, et al. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020;8:572923.