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SNAP-8 10mg

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Buy 1 Get 1 Free SNAP-8 10MG :

Unit Size 10 mg/ vial
Unit Quantity 1 vial
Purity (Mass Spectrometry and UV) 94.06%
Sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Molecular Formula C41H70N16O16S
Molecular Mass 1074.48
Synonyms Acetyl Glutamyl Heptapeptide-3
Appearance Lyophilized White Powder
Source Chemical Synthesis
Storage
Lyophilized SNAP-8 is Stable at room
Temperature for 90 days, however it is best to store
in a freezer below - 8c for any extended
period of time. After reconstitution SNAP-8 should be
refrigerated at temperatures not to exceed 35 F.
Terms The products we offer are intended for laboratory
research use only. Please familiarize yourself with
our terms of service prior to ordering.

 

SNAP-8 is a synthetic neuropeptide composed of the N-terminal end of the SNAP-25 peptide. Also known as acetyl glutamyl heptapeptide-1, SNAP-8 has been used as a cosmetic peptide known for its anti-wrinkle and fine-line properties. It consists of 8 amino acids and has a molecular weight of 1074.5 g/mol. SNAP-25 interacts with the SNARE complex (specifically, syntaxin and synaptobrevin) to cellular transport and fusion of vesicles carrying neurotransmitters.1 SNAP-8 functions similarly to SNAP-25, but it does not bind exactly the same, destabilizing the complex slightly. As a result, the SNARE complex cannot facilitate the release of neurotransmitters such as catecholamine, subsequently reducing muscle contractions.2 In animal studies, the effects of SNAP-8 have shown to help the skin relax, preventing fine lines and wrinkles. SNAP-8 studies have also shown it can be used as an alternative to botulinum toxin injections for treating lines and wrinkles.3 Studies performed with SNAP-8, show that it is an effective treatment. One report with 17 subjects used silicon imprints to measure improvement of eye wrinkles after 28 days of treatment using a 10% formulation of SNAP-8. The results showed that there was a maximum wrinkle reduction of 62%, with a mean of 35%.4

Blue Sky Peptide’s SNAP-8 is available as a white lyophilized powder at a concentration of 10 mg/vial. SNAP-8 is intended for vitro scientific research.

References: 1. Han J, Pluhackova K, Bockmann RA. The Multifaceted Role of SNARE Proteins in Membrane Fusion. Front Physiol. 2017;8:5. 2. Gutierrez LM, Viniegra S, Rueda J, et al. A Peptide That Mimics the C-terminal Sequence of SNAP-25 Inhibits Secretory Vesicle Docking in Chromaffin Cells. J Biol Chem. 1997;272(5):2634-9. 3. Wongrattanakamon P, Nimmanpipug P, Sirithunyalug B, Jiranusornkul S. Molecular modeling elucidates the cellular mechanism of synaptotagmin-SNARE inhibition: a novel plausible route to anti-wrinkle activity of botox-like cosmetic active molecules. Mol Cell Biochem. 2018;42:97-109. 4. Errante F, Ledwon P, Latajka R, et al. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020;8:572923.