Selank 10mg

Selank is a synthetic peptide analog of the natural human protein tuftsin. Originally discovered at Tufts University in 1983, tuftsin is a tetrapeptide that consists of 4 amino acids and comes from the Fc-domain of the heavy chain of immunoglobulin (Ig) G. Tuftsin has known immunomodulatory effects, and it plays a role in antigen processing, formation of reactive oxygen species, and formation of antigen complexes.^1,2 Selank is similar in structure to tuftsin but contains an additional 3 amino acids on the C-terminus of the peptide (Pro-Gly-Pro).³ The addition of these residues helps improve the half-life of the peptide through increased metabolic stability. Selank was originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences.⁴ Since its creation, Selank has been studied for its purported anti-anxiety, immunomodulatory, and nootropic effects. Reports show that Selank has similar effects to antidepressants by increasing the concentration of monoamine neurotransmitters, in addition to influencing the brain’s serotonin metabolism. These effects are seen in the antidepressant effects in animal models of depression. Selank also has antistress effects that help alleviate fear and aggression in other animal models.³ Stressful situations induce the expression of pro- and anti-inflammatory cytokines. In a rat model of social stress, Selank reduced levels of inflammatory cytokines such as interleukin (IL)-6 and IL-1beta, while returning IL-4 levels to their normal state.⁵ In fact, Selank has been compared to low-dose tranquilizers and benzodiazepines for its anxiolytic effects, but without the unwanted side effects. This highlights the usefulness of the peptide in in vivo studies.^6,7 In addition, Selank has been studied for its nootropic effects and ability to improve learning and memory.^8,9

Selank is available in a white lyophilized powder form with a molecular mass of 751.43 g/mol. It comes at a concentration of 10 mg per glass vial.

References: 1 Fridkin M, Najjar VA. Tuftsin: Its Chemistry, Biology and Clinical Potential. Crit Rev Biochem Mol Biol. 1989;24:1-40. 2. Najjar VA. Tuftsin, a natural activator of phagocyte cells: an overview. Ann New York Acad Sci. 1983:1-11. 3. Volkova A, Shadrina M, Kolomin T, Andreeva L, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016;7:31. 4. Filatova E, Kasian A, Kolomin T, Rybalkina E, et al. GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Front Pharmacol. 2017;8:89. 5. Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, Aleksandrovna BO, et al. The Influence of Selank on the Level of Cytokines Under the Conditions of “Social” Stress. Curr Rev Clin Exp Pharmacol. 2021;16(2):162-167. 6. Seredenin SB, YuA B, Badyshtov BA, Gordey ML, Nagovitsina YA. Pharmacogenetic analysis of mechanisms of emotional stress: effects of benzodiazepines. Ann Ist Super Sanita. 1990;26(1):81-7. 7. Seredenin SB, Kozlovskaia MM, Blednov IA, Kozlovski II, et al. [The anxiolytic action of an analog of the endogenous peptide tuftsin on inbred mice with different phenotypes of the emotional stress reaction.] Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Jan-Feb;48(1):153-60. 8. Narkevich VB, Kudrin VS, Klodt PM, Pokrovski AA, et al. [Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study.] Eksp Klin Farmakol. 2008 Sep-Oct;71(5):8-12. 9. Sokolov OY, Meshavkin VK, Kost NV, Zozulya AA. Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. Bull Exp Biol Med. 2002 Feb;133(2):133-5.