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Phospho DSIP 5mg

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Buy Phospho DSIP 5mg :

Unit Size 5 mg/ vial
Unit Quantity 1 vial
Purity (Mass Spectrometry and UV) 99.5%
Sequence H-Trp-Ala-Gly-Gly-Asp-Ala-{pSer}-Gly-Glu-OH
Molecular Formula C35H49N10O18P
Molecular Mass 928.30
Synonyms Delta Sleep Inducing Peptide, DSIP
Appearance Lyophilized White Powder
Source Chemical Synthesis
Storage
Lyophilized Phospho DSIP is Stable at room
Temperature for 90 days, however it is best to store
in a freezer below - 8c for any extended
period of time. After reconstitution Phospho DSIP should be
refrigerated at temperatures not to exceed 35 F.
Terms The products we offer are intended for laboratory
research use only. Please familiarize yourself with
our terms of service prior to ordering.

 

Phospho DSIP is a natural peptide originally isolated from cerebral venous blood from rabbits in the 1970s.1 Known as delta sleep-inducing peptide, DSIP is a small peptide that contains nine amino acids. Blue Sky Peptide has added a phosphate group on the serine in position 7. The molecular weight is 928.30 g/mol. While DSIP was originally studied for its role in sleep, researchers have found mixed results. Some studies show its role in promoting slow-wave sleep, while others have not been able to replicate these results.2,3 Despite this, further investigation into DSIP’s effects has uncovered many other functions of the peptide. These include roles in hormone regulation, pain management, and cancer treatment. DSIP is known to regulate several hormones, such as decreasing corticotropin levels, which play a role in regulating the hypothalamic-pituitary-adrenal axis and modulate stress response.4 DSIP also stimulates the release of luteinizing hormone (LH) in rat models, which is hypothesized to play a physiological role in sleep.5 Research in rat models has also demonstrated that DSIP has pain-relieving effects.6 Researchers from one study also found that DSIP may be useful in those who are dependent on pain medications due to its ability to diminish discomfort and withdrawal symptoms.7 Finally, DSIP has been researched for its potential role in preventing cancer. A study conducted in mice that received either placebo or DSIP for five consecutive days every month found that the DSIP-treated mice had a 2.6-fold decrease in tumor development. While these results show promise for DSIP as a cancer vaccine, more studies are needed to confirm the findings.8

Blue Sky Peptide’s Phospho DSIP is available as a white lyophilized powder at a concentration of 5 mg/vial. Phospho DSIP is intended for in vitro scientific research.

References 1. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-309. 2. Iyer KS, Marks GA, Kastin AJ, McCann SM. Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat. Proc Natl Acad Sci USA. 1988;85(10):3653-3656. 3. Nakagaki K, Ebihara S, Usui S, et al. [Effects of intraventricular injection of anti-DSIP serum on sleep in rats.] Yakubutsu Seishin Kodo. 1986;6(2):259-265. 4. Schoenenberger GA. Characterization, Properties and multivariate functions of delta-sleep-inducing peptide (DSIP). Eur Neurol. 1984;23(5):321-345. 5. Iyer KS, McCann SM. Delta sleep inducing peptide (DSIP) stimulates the release of LF but not FSH via a hypothalamic site of action in the rat. Brain Res Bull. 1987;19(5):535-538. 6. Nakamura A, Nakashima M, Sugao T, et al. Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP). Eur J Pharmacol. 1988;155(3):247-253. 7. Larbig W, Gerber WD, Kluck M, Schoenenberger GA. Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study. Eur Neurol. 1984;23(5):372-385. 8. Popovich IG, Voitenkov BO, Anisimov VN, et al. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span, and spontaneous tumor incidence in female SHR mice. Mech Ageing Dev. 2003;124(6):721-731.