GHRP-6 5mg

GHRP-6 is a synthetic mimetic of ghrelin. Also known as growth hormone-releasing peptide 6 or growth hormone-releasing hexapeptide, GHRP-6 is a growth hormone secretagogue that was originally discovered to bind to the growth hormone secretagogue receptor (GHS-R). Later on, researchers found that the GHS-R indeed had an endogenous ligand, known as ghrelin. With this, GHRP-6 is considered a mimetic of ghrelin. Ghrelin contains 28 amino acids and is known to play a role in signaling hunger and regulating food intake, along with stimulating growth hormone (GH) release.¹ GHRP-6 is distinct from growth hormone-releasing hormone (GHRH), as they share no amino acid sequence and bind to different receptors. Interestingly, the two hormones do have synergistic effects when administered together, increasing GH release. This is because GHRP-6 has both pituitary and hypothalamic effects.²GHRP-6 contains only 6 amino acids, including unnatural D-amino acids, and has a molecular weight of 929.48 g/mol. The sequence is as follows: L-Histidine, D-Tryptophan, L-Alanine, L-Tryptophan, D-Phenylalanine, and L-Lysine. The addition of D-amino acids into the synthetic peptide allows it to still stimulate GH secretion from the anterior pituitary gland while blocking the function of somatostatin, which blocks GH release. GH then stimulates insulin-like growth factors (IGFs), which play a role in metabolism, cell proliferation, and protein synthesis.¹ One study in fish found that supplementing feed with either 100 µg/kg or 500 µg/kg of GHRP-6 increased growth performance. The lower dose improved aerobic metabolism, but the higher dose increased GH levels on par with ghrelin.¹ Other studies have found that GHRP-6 has neuroprotective effects in cases of ischemic stroke. In a gerbil model of stroke, the combination of GHRP-6 and recombinant epidermal growth factor (rhEGF) improved both neurological outcomes and survival.³

GHRP-6 is available as a white lyophilized powder at a concentration of 5 mg/vial. This product is intended for laboratory research purposes only.

References: 1. Rodriguez-Viera L, Marti I, Martinez R, et al. Feed Supplementation with the GHRP-6 Peptide, a Ghrelin Analog, Improves Feed Intake, Growth Performance and Aerobic Metabolism in the Gilthead Sea Bream Sparus aurata. Fishes. 2022;7:31. 2. Popovic V, Damjanovic S, Micic D, et al. Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level. J Clin Endocrinol Metab. 1995;80(3):942-7. 3. Subiros N, Perez-Saad HM, Berlanga JA, et al. Assessment of dose-effect and therapeutic time window in preclinical studies in rhEGF and GHRP-6 coadministration for stroke therapy. Neurol Res. 2016;28(3):187-95.