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FRAGMENT 176-191 2mg

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Buy 1 Get 1 Free FRAGMENT 176-191 2mg :

Unit Size 2 mg/vial
Unit Quantity 1 vial
Purity (Mass Spectrometry and UV) 97.6%
Sequence H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH
Molecular Formula C78H123N23O23S2
Appearance Lyophilized White Powder
Source Chemical Synthesis
Storage
Lyophilized FRAGMENT 176-191 is Stable at room
Temperature for 90 days, however it is best to storer
in a freeze below - 8c for any extended period of time.
After reconstitution FRAGMENT 176-191 should be
refrigerated at temperatures not to exceed 35 F.
Terms The products we offer are intended for laboratory
research use only. Please familiarize yourself with
our terms of service prior to ordering.

Click here to read more about HGH FRAG 176-191 peptide on our research blog

Fragment 176-191 is a synthetic analog of human growth hormone (hGH). It only contains the 16 amino acids from the C-terminus of the hGH peptide, spanning from positions 176-191. Substitution of tyrosine to phenylalanine at position 191 enhances the peptide’s ability to break down lipids.1 It is a small peptide with a molecular weight of 1812 g/mol. Fragment 176-191 is known to mimic the function of growth hormone-releasing factor (GHRF), also known as growth hormone-releasing hormone (GHRH). Endogenously, GHRH triggers the pituitary gland to release growth hormone (GH).2 Fragment 176-191 is often referred to as the “lipolytic fragment” due to its ability to promote fat loss. Studies in mouse models that were genetically engineered to have larger fat stores found that administration of fragment 176-191 boosted fat loss. These effects are mediated through the peptide’s binding to beta-3 adrenergic receptors (ADRB3), particularly in adipose tissue. This finding was confirmed with mice that have a genetic knockout of ADRB3 — the fat loss effects of fragment 176-191 were not observed in these mice.3 Studies also show that fragment 176-191 induces thermogenesis in skeletal muscle, which contributes to the basal metabolic rate of organisms.4 Other studies showcase the peptide’s role in regulating blood sugar levels. Fragment 176-191 gradually increases insulin levels, subsequently lowering blood sugar in animal models. As a result, the peptide has some interest in being investigated as a potential treatment for diabetes.5 Fragment 176-191 is also hypothesized to play a role in cartilage regeneration. Weekly administration of the peptide both alone and alongside hyaluronic acid in rabbits found that it enhanced cartilage regeneration. In a rabbit model of osteoarthritis, fragment 176-191 alone or in combination with hyaluronic acid was also observed to reduce disability.6

Fragment 176-191 is available as a lyophilized white powder at a concentration of 2 mg/vial. This product is intended for laboratory research use only.

References: 1. Habibullah MM, Mohan S, Syed NK, et al. Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells. Drug Des Devel Ther. 2022;16:1963-1974. 2. Harvey S, Martinez-Moreno CG. Growth Hormone: Therapeutic Possibilities—An Overview. Int J Mol Sci. 2018;19(7):2015. 3. Heffernan M, Summers RJ, Thorburn A, et al. The Effects of Human GH and Its Lypolytic Fragment (AOD9604) on Lipid Metabolim Following Chronic Treatment in Obese Mice and β3-AR Knock-Out Mice. Endocrinology. 2001;142(12):5182-9. 4. Ferrer-Lorente R, Cabot C, Fernandez-Lopez, J, Alemany M. Combined effects of oleoyl-estrone and a beta3-adrenergic agonist (CL316,243) on lipid stores of diet-induced overweight male Wistar rats. Life Sci. 2005;77(16):2051-8. 5. Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978;234(5):E521-6. 6. Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015;45(4):426-32.