October 2014

SNAP 8 peptide’s scientific name is Acetyle Glutamyl Heptapeptide-1. It is being tested for use for anti-wrinkle solutions. Studies show that SNAP 8 has properties that enable it to reduce the depth of wrinkles that are caused by everyday muscle contractions. In animal test subjects, it has shown significant results around the eyes and forehead. This product is considered to be a milder, more cost-effective and safer alternative to Botulinum Toxin. SNAP 8 works similarly to Botulinum Toxin by targeting the same wrinkle formations, but in a unique way. Test Results of SNAP 8 Peptide VIVO testing was performed to determine how effective small peptides are with providing stability for the SNARE complex. This allowed the researchers to follow the thermal stability and formation of the reconstituted SNARE protein complex. This basically evaluates the effectiveness of the peptides that are patterned like SNAP-25 N and its ability to amass with synaptobrein and syntaxin that is being formed with the SNARE complex. The final result was that the short peptides that came from the N-terminal end of SNP-25 were able to compete with the natural protein and stop it from forming SNARE complex by changing the stability. Another test was done with test subjects. The cream used consisted of 10 percent SNAP 8. Researchers obtained silicon imprints from around the eyes of 17 test subjects. These silicon imprints were taken before the test began. The test subjects applied the cream twice daily, and then another sample was taken 28 days later. The imprints were analyzed using control laser scanning microscopy to see the difference between the skin surface of the sample taken before and after treatment. In order to see a three dimensional view of the samples, skin topography images were created. Within these images, it was observed that the depth of the wrinkles had decreased significantly after receiving treatment for 28 days. The max reduction that was seen with the 10 percent SNAP 8 solution was 63.18 percent. How SNAP 8 Peptides Work SNAP 8 is a copy of the N-terminal end of SNAP-25. This competes with SNAP-25 to position itself within the SNARE complex, which then modulates its creation. When the SNARE complex is destabilized slightly, it is impossible for the vesicle to release neurotransmitters in an efficient manner. Because of this, muscle contractions are reduced, so that wrinkles and lines are prevented. It will also help reduce existing fine lines and wrinkles by inhibiting the formation of SNARE complex and the release of catecholamine. With regular use in test subjects, it also prevented the development of wrinkles and lines. Clinical studies show that SNAP 8 helped to reduce wrinkles surrounding the eyes by up to 63.13 percent. Testing for vitro and vivo efficiency showed that SNAP 8 has 30 percent more activity than parent peptides like Argireline. Disclaimer: SNAP 8 peptide is a solution that is still currently being tested in the scientific community. It is not intended for use on humans or animals. It is recommended to purchase SNAP 8 for the sole purpose of experimentation within a laboratory setting. It should not be purchased and used for any other reason. This substance has not been approved for use by people. It is recommended that experiments conducted with SNAP 8 be performed under experimental circumstances that are under strict lab guidelines. Safety equipment should be used at all times throughout experimentation with this product. In the event that someone is exposed to the substance, thorough cleansing of the area immediately after is recommended to avoid potential harm.

Thymosin Beta4 is a peptide that was first found within the thymus gland. Since its discovery, other types of thymosin have been found in different tissues throughout test subjects. Thymosin Beta 4 is typically found in both types of muscles – skeletal (the muscles that are required to move) and smooth muscles (such as the heart). When damage occurs in a tissue, Thymosin Beta 4 is upregulated. Then when traumas take place, Thymosin Beta 4 is released in order to help the subject heal from the trauma. This peptide also helps to prevent adhesions from forming, which means there will be less scar tissue and potentially more flexibility. It has potent anti-inflammatory characteristics. Thymosin Beta 4 is a potent peptide that comes from a family of 16 related molecules that are localized in circulating cells and tissues within the body. These molecules also have a high conservation of sequence. TB 500 conjoins with actin and prevents actin polymerization. It is noted as being the actin-sequestering molecule within eukaryotic cells. It also boosts extracellular matrix-degrading enzyme production. The Benefits of Thymosin Beta 4 Thymosin Beta 4 is a protein that is made up of 43 amino acids. The TMSB4X gene found in the test subject's body encodes the peptide. There have been a variety of clinical trials that have been performed using this peptide. In the research, it’s been found that the Thymosin Beta 4 may be used after a heart attack takes place in order to reactivate the cells in the cardiac progenitor, so that repair can be done to the damaged tissue in the heart. The molecule of this peptide is very big, so it isn’t able to completely fit within a receptor. Each area of the molecule has different functions. For instance, TB 500 is responsible for promoting majority of the useful effects, such as the healing, muscle cells, new blood and repair. In some scenarios, TB 500 could be used rather than the whole Thymosin Beta 4 protein. TB 500’s main ability is to regulate Actin, which is a cell-building protein. There are thousands of proteins found inside of cells, but actin makes up to 10 percent of the total amount of proteins, giving it a major role in the cell’s genetic makeup. Some of the benefits associated with TB 500 include:

• Increased muscle growth
• Increased endurance
• Calmed muscle spasms
• Muscle tone improvement
• Improved substance exchanges between cells
• Promotes tissue repair
• Allows connective tissue to stretch
• Maintains flexibility
• Reduces joint tissue inflammation
• Stops adhesions and fibrous bands from forming on ligaments, muscles and tendons

Research behind Thymosin Beta 4 The studies that have been conducted have determined that this peptide is potent and that it occurs totally naturally. It does help to repair wounds using its anti-inflammatory characteristics. Unlike with growth factors and other repair factors, this peptide increases the migration of endothelial and keratinocyte. It also does not conjoin to extracellular matrixes and is noted as having a molecular weight that is very low, which enables it to travel far distances within tissues. Disclaimer: Thymosin Beta 4 is a peptide that should only be purchased for use in experimentation and research. It should not be purchased for human use or any other purpose than for research. It is advised that once purchased, the peptide is used within experimental circumstances that are under strict lab regulations. It is recommended that researchers use protective gear in order to prevent contact with the substance. However, if exposure is made with the peptide, it is very important to cleanse the area immediately to prevent harm.

Hexarelin is a research peptide that’s under the classification of growth hormone releasing peptides, also known as GHRPs or GH secretagogues. Other forms of GHRPs include GHRP-6, GHRP-2 and Ipamorelin. Hexarelin is mainly used to provide pituitary gland stimulation, which causes a production of growth hormones. Like its GHRP counterparts, Hexarelin has a 2-step action plan that consists of suppressing Somatostatin actions, while increasing growth hormones (by amplifying the signal transduction pathway of growth hormone releasing hormones, also known as GHRH). What Makes Hexarelin Different from the Other GHRPs? When you look at the data, you’ll see that Hexarelin has characteristics that are unique from the other GHRPs mentioned above. In fact, it is the most potent of the growth hormone releasers. It out performs the other GH releasing peptide when you view the numbers on a mcg to mcg basis. There is also evidence (not yet proven) that there is higher rapidity rate of desensitization compared to the other research peptides, but the extent and the rate are still being studied. It’s recommended to researchers that they discontinue using Hexarelin within 2 weeks of starting use on test subjects. Going past this point may cause the GH to have an insignificant spike, due to the enhanced desensitization. However, there is a study that goes against this theory. Study Done on the Rate of Desensitization of Hexarelin Scientific research on animal test subjects were used in a study to determine the rate of desensitization of Hexarelin when it’s administered daily. Blood work from the animal test subjects were taken at the end of the week on weeks 1, 2, 4 and 16. The blood was then evaluated and conclusions were met that Hexarelin showed little difference in desensitization after one week and four weeks of administration. The doses included 1mg/kg and 2mg/kg daily. After the 16 week mark, the amount of growth hormone released was blunted. What is Hexarelin Used for? When Hexarelin was injected into animal test subjects, it has shown to have effects that include increased size of muscle fibers, neural protection, increased strength, new muscle fiber growth, joint rejuvenation, joint protection and joint healing. It is also believed to reduce the amount of fatty tissue, helping the test subject to lose fat. The growth is only due to the increase in hormones – it doesn’t boost appetite or quicken gastric emptying. Results of Hexarelin in Test Subjects The animal test subjects that used Hexarelin saw growth in muscle size due to the new muscle cell creation. Some even witnessed a more youthful appearance. It’s also shown to have quick healing for injuries. In some instances, cardiac benefits were seen. This peptide was used on some animal test subjects that have an inability to naturally produce their own growth hormones or who are seeking to look younger. Hexarelin is known to improve the elasticity of the skin. Overweight and athletic animal test subjects were also used and good results were achieved. Overall, it assists with fat reduction, injury healing and prevention, skin elasticity and muscle building. Disclaimer: It’s important to note that Hexarelin is a peptide and is only to be used in clinical research studies. This should in no way be used for human consumption. Hexarelin should only be purchased for the sole purpose of vitro research being conducted in a laboratory setting, under strict guidelines. In the event that you or any of the researchers are exposed to this peptide, be sure to cleanse it immediately to prevent harm to the individual. Hexarelin is a peptide that is still under research for the purposes of scientific studies.

Pramipexole is a research liquid that has been used in studies on animal test subjects that suffer from Parkinson’s disease and other disorders that relate to the nervous system and exhibit difficulties moving, balancing and controlling muscles. Studies on animal test subjects have indicated that It may help to reduce the symptoms of Parkinson’s disease, such as stiffness, inability to balance, shaking body parts and slowed movements. Another study on animal test subjects indicated that Pramipexole showed improvements in restless legs syndrome, which is when the legs have a discomfort and there is a strong urge to move them. This constant leg movement mainly happens during the night, while lying down or sitting. You’ll find this research liquid under the classification of dopamine agonists. Studies have also shown on animal test subjects, it replaces dopamine, which is a natural substance located in the brain, and is needed to help animal test subjects control movement. Side Effects of Pramipexole Although Pramipexole is still being studied, there are side effects that have shown to be prevalent in some animal test subjects. One particular side effect is falling asleep during normal daily activities after being fully alert, such as while eating, moving around, or getting clean. Studies on animal test subjects have concluded It is not recommended that any type of strenuous activity come after exposure to this research liquid. Studies indicate that intense urges may also arise, such as increased desire to have sex, eat odd things, or any other urges that aren’t normally present. The animal test subjects who shown to have restless leg syndrome sometimes have symptoms that grow worse or begin to witness restless symptoms in their arms and hands. In some instances, it may even cause hallucinations, but this is mainly amongst the elderly animal test subjects. Here is a list of the other side effects that have been associated with Pramipexole studies:

• Nausea, weakness, sweating, fainting or light-headedness
• Muscle tenderness, pain or weakness, along with a fever or flu-like symptoms and urine that is dark-colored
• Pain in the chest, coughing up mucus that is pink or white, and wheezing
• Shortness of breath, rapid weight gain, swelling
• Tremors in the eyes, tongue, lips, legs, face, or arms
• Feeling weak or tired, appetite loss, or rapid weight loss
• Blurred vision
• Impotence, loss desire to have sex
• Amnesia, problems thinking, insomnia, unusual dreams

Other Uses of Pramipexole Other than being used for restless leg syndrome and Parkinson’s disease, there have also been studies conducted on animal test subjects who suffer from bipolar depression and unipolar depression. In the study for bipolar depression, twenty-one animal test subjects were given Pramipexole and it showed to be highly effective as treatment. The dosage was three times daily at 0.125 mg, and then was increased by 0.125 mg three times daily until 4.5 mg daily doses were reached. This is when the animal test subjects showed satisfactory responses to the research liquid or weren’t able to abide the side effects. The unipolar depression study also carried a controlled study and the results were efficacious in treating the condition. More research studies are being done with Pramipexole for other health problems, like cluster headaches, which is a reoccurring severe headache that appears on one side of the head, usually near the eye. It has also been used on animal test subjects who have sexual dysfunction due to taking selective serotonin reuptake inhibitor antidepressants, also known as SSRIs. Currently, this research liquid is being studied to determine if it can successfully treat clinical depression and fibromyalgia. Disclaimer: Pramipexole is a research liquid that should not be consumed by people. It should only be purchased for the purpose of conducting studies. Research projects should be performed in a lab setting using protective gear. Strict laboratory guidelines should be adhered to while testing this research liquid on subjects. It is also recommended that you immediately rinse the research liquid off of your skin if exposed to it.