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Blend CJC 1295 NO DAC 5MG with GHRP-2 5MG

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Buy 2 Get 1 Free Blend CJC 1295 NO DAC 5MG with GHRP-2 5MG :

Unit Size 10 mg/ vial
Unit Quantity 1 vial
Purity (Mass Spectrometry and UV) 99.2%
Appearance Lyophilized White Powder
Source Chemical Synthesis
Storage
Lyophilized Blend CJC 1295 NO DAC with GHRP-2 is Stable
at roomTemperature for 90 days, however it is best to store in a freezer
below - 8c for any extended period of time. After reconstitution
Blend CJC 1295 NO DAC with GHRP-2 should be
refrigerated at temperatures not to exceed 35 F.
Terms The products we offer are intended for laboratory
research use only. Please familiarize yourself with
our terms of service prior to ordering.

 

CJC 1295 NO/DAC with GHRP-2 is a synthetic analog of the growth hormone-releasing hormone (GHRH). This specific formulation also contains the peptide GHRP-2. CJC-1295 contains 30 amino acids and has a molecular weight of 3647.16 g/mol. This peptide was derived from another synthetic peptide, sermorelin (also known as GHRH 1-29). CJC-1295 can be formulated with or without the drug affinity complex (DAC). However, this specific formulation does not contain DAC. This means that the peptide will have a significantly lower half-life than formulations containing DAC. CJC-1295 with DAC can bioconjugate with albumin, increasing its half-life and therapeutic window. It also has protecting groups around the amino acids of GHRH that are typically degraded by enzymes, further contributing to its longer half-life.1 This is an improvement over the half-life of endogenous GHRH, which is around 7 minutes. Using CJC-1295 can allow researchers to study different pathways for longer periods of time.2 One study in a GHRH knockout mouse model found that CJC-1295 treatment causes normal growth hormone release without interfering with downstream pathways, such as insulin-like growth factor-1 (IGF-1) release.3 Growth hormone-releasing peptide-2 (GHRP-2) is a synthetic agonist of ghrelin, the gut peptide that stimulates appetite, along with the release of growth hormone. GHRP-2 binds to the growth hormone secretagogue receptor.4 Together, these two peptides increase the secretion of growth hormone and IGF-1. Both CJC-1295 and GHRP-2 have been used in in vitro and in vivo studies looking at cardiac function, the immune system, and muscle strengthening. These peptides have both been found to improve lean muscle mass and reduce fat in studies of healthy adults.2,5 While studies have used CJC-1295 and GHRP-2, this formulation is not approved for these purposes. CJC-1295 NO/DAC with GHRP-2 is for laboratory research use only.

CJC 1295 NO/DAC with GHRP-2 is available at a concentration of 5mg X 2 = 10mg per vial for use in in vitro studies.

References: 1. Jette L, Leger R, Thibaudeau K, et al. Human Growth Hormone-Releasing Factor (hGRH) 1-29 - Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long-Lasting GRF Analog. Endocrinology. 2005 Jul;146(7):3052-3058. 2. Teichman SL, Neale A, Lawrence B, et al. Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. 3.Alba M, Fintini D, Sagazio A, et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. 4. Laferrere B, Abraham C, Russell CD, Bowers CY. Growth Hormone Releasing Peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. 2005 Feb;90(2):611-614. 5. Sigalos JT, Pastuszak AW, Allison A, et al. Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels. Am J Mens Health. 2017 Nov;11(6):1752-1757.